Name: FM26
Rating: 5 (10 reviews)

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HIT ID:HIT212670846
Cas No:2407981-35-3
常用名:FM26
IUPAC:4-[({3-[2-chloro-6-(trifluoromethyl)phenyl]-5-(1H-pyrrol-3-yl)-1,2-oxazol-4-yl}methyl)amino]benzoic acid
IUPAC:4-[({3-[2-chloro-6-(trifluoromethyl)phenyl]-5-(1H-pyrrol-3-yl)-1,2-oxazol-4-yl}methyl)amino]benzoic acid
InChI key:KGEONJPJJNFHOI-UHFFFAOYSA-N

分子式:C22H15ClF3N3O3
分子量:461.83
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:5.354705
SMILES:OC(=O)c1ccc(NCc2c(noc2-c2cc[nH]c2)-c2c(Cl)cccc2C(F)(F)F)cc1
SMILES:OC(=O)c1ccc(NCc2c(noc2-c2cc[nH]c2)-c2c(Cl)cccc2C(F)(F)F)cc1

FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM.

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