Name: Forodesine hydrochloride
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212670857
Cas No:284490-13-7
常用名:Forodesine hydrochloride
别名:Immucillin-H hydrochloride, BCX-1777 hydrochloride
别名:Immucillin-H hydrochloride, BCX-1777 hydrochloride
IUPAC:7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride
IUPAC:7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride
InChI key:WEIAMZKHBCLFOG-QPAIBFMUSA-N

分子式:C11H15ClN4O4
分子量:302.72
氢键供体数 (HBD):6
氢键受体数 (HBA):7
LogP:-2.5962675
SMILES:Cl.OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1[nH]cnc2=O
SMILES:Cl.OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1[nH]cnc2=O

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~