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  3. HIT212670879
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HIT212670879
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HIT212670879
  • HIT ID:HIT212670879
  • Cas No:73819-26-8
  • 常用名:Furamidine
  • 别名:NSC 305831, DB75
  • IUPAC:4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzene-1-carboximidamide
    IUPAC:4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzene-1-carboximidamide
  • InChI key:ZJHZBDRZEZEDGB-UHFFFAOYSA-N
  • 分子式:C18H16N4O
  • 分子量:304.353
  • 氢键供体数 (HBD):4
  • 氢键受体数 (HBA):4
  • LogP:2.0888813
  • SMILES:NC(=N)c1ccc(cc1)-c1ccc(o1)-c1ccc(cc1)C(N)=N
    SMILES:NC(=N)c1ccc(cc1)-c1ccc(o1)-c1ccc(cc1)C(N)=N
  • Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA.
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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