Name: γ-Secretase modulator 4
Rating: 5 (10 reviews)

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HIT ID:HIT212670905
Cas No:1420200-82-3
常用名:γ-Secretase modulator 4
IUPAC:2-[(8S)-8-(3-fluoro-2-methylphenyl)-5H,6H,8H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1H-indole-5-carbonitrile
IUPAC:2-[(8S)-8-(3-fluoro-2-methylphenyl)-5H,6H,8H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy-1H-indole-5-carbonitrile
InChI key:UBJJQXXWGRHIDV-QFIPXVFZSA-N

分子式:C23H19FN4O2
分子量:402.429
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.1986866
SMILES:COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1cccc(F)c1C)C#N
SMILES:COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1cccc(F)c1C)C#N

γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.

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