Name: GC 14
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

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HIT ID:HIT212670923
Cas No:447415-34-1
常用名:GC 14
IUPAC:2-(4-{[6-hydroxy-4'-nitro-5-(propan-2-yl)-[1,1'-biphenyl]-3-yl]methyl}-3,5-dimethylphenoxy)acetic acid
IUPAC:2-(4-{[6-hydroxy-4'-nitro-5-(propan-2-yl)-[1,1'-biphenyl]-3-yl]methyl}-3,5-dimethylphenoxy)acetic acid
InChI key:PBZAEAFSLYJVGD-UHFFFAOYSA-N

分子式:C26H27NO6
分子量:449.503
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:6.940848
SMILES:CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(c1O)-c1ccc(cc1)[N+]([O-])=O
SMILES:CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(c1O)-c1ccc(cc1)[N+]([O-])=O

GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.

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