Name: AZD-8529
Rating: 5 (10 reviews)

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HIT ID:HIT212670962
Cas No:1092453-15-0
常用名:AZD-8529
IUPAC:7-methyl-5-{3-[(piperazin-1-yl)methyl]-1,2,4-oxadiazol-5-yl}-2-{[4-(trifluoromethoxy)phenyl]methyl}-2,3-dihydro-1H-isoindol-1-one
IUPAC:7-methyl-5-{3-[(piperazin-1-yl)methyl]-1,2,4-oxadiazol-5-yl}-2-{[4-(trifluoromethoxy)phenyl]methyl}-2,3-dihydro-1H-isoindol-1-one
InChI key:IPCYZQQFECEHLI-UHFFFAOYSA-N

分子式:C24H24F3N5O3
分子量:487.483
氢键供体数 (HBD):1
氢键受体数 (HBA):6
LogP:3.473
SMILES:Cc1cc(cc2CN(Cc3ccc(OC(F)(F)F)cc3)C(=O)c12)-c1nc(CN2CCNCC2)no1
SMILES:Cc1cc(cc2CN(Cc3ccc(OC(F)(F)F)cc3)C(=O)c12)-c1nc(CN2CCNCC2)no1

AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

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