Name: BAY 60-2770
Rating: 5 (10 reviews)

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HIT ID:HIT212670993
Cas No:1027642-43-8
常用名:BAY 60-2770
IUPAC:4-{[(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl]methoxy}phenyl)ethyl]amino]methyl}benzoic acid
IUPAC:4-{[(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl]methoxy}phenyl)ethyl]amino]methyl}benzoic acid
InChI key:CRQMDXFUKDWARU-UHFFFAOYSA-N

分子式:C35H33F4NO5
分子量:623.645
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:5.302691
SMILES:OC(=O)CCCCN(CCc1cc(F)ccc1OCc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)Cc1ccc(cc1)C(O)=O
SMILES:OC(=O)CCCCN(CCc1cc(F)ccc1OCc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)Cc1ccc(cc1)C(O)=O

BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator with antifibrotic effect. It increases the activity of sGC in a nitric oxide-independent manner.

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