Name: BAY-899
Rating: 5 (10 reviews)

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HIT ID:HIT212671003
Cas No:2471967-92-5
常用名:BAY-899
IUPAC:(5S)-N-[2-(4-fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxamide
IUPAC:(5S)-N-[2-(4-fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxamide
InChI key:VKQBTIMLSDGNLG-QHCPKHFHSA-N

分子式:C25H19F2N5O2
分子量:459.457
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.2264824
SMILES:Fc1ccc(Oc2ncc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(F)cc3)cn2)cc1
SMILES:Fc1ccc(Oc2ncc(NC(=O)N3CCc4ncccc4[C@@H]3c3ccc(F)cc3)cn2)cc1

BAY-899 is an orally active and selective antagonist of the luteinizing hormone receptor (LH-R), exhibiting IC50 values of 185 nM and 46 nM for human LH (hLH) and rat LH (rLH) respectively. In vivo studies have demonstrated that BAY-899 effectively reduces sex hormone levels[1].

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