Name: BLM-IN-1
Rating: 5 (10 reviews)

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HIT ID:HIT212671069
Cas No:2056014-40-3
常用名:BLM-IN-1
IUPAC:(3E)-6-{[3-(diethylamino)propyl]amino}-7-fluoro-3-{[4-(propan-2-yl)phenyl]methylidene}-1H,2H,3H,9H-pyrrolo[2,1-b]quinazolin-9-one
IUPAC:(3E)-6-{[3-(diethylamino)propyl]amino}-7-fluoro-3-{[4-(propan-2-yl)phenyl]methylidene}-1H,2H,3H,9H-pyrrolo[2,1-b]quinazolin-9-one
InChI key:GZSNGNPLURZQGM-CJLVFECKSA-N

分子式:C28H35FN4O
分子量:462.613
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.9312754
SMILES:CCN(CC)CCCNc1cc2nc3\C(CCn3c(=O)c2cc1F)=C\c1ccc(cc1)C(C)C
SMILES:CCN(CC)CCCNc1cc2nc3\C(CCn3c(=O)c2cc1F)=C\c1ccc(cc1)C(C)C

BLM-IN-1 is an effective Bloom syndrome protein (BLM) inhibitor (KD: 1.81 μM; IC50: 0.95 μM). It induces DNA damage response, apoptosis and proliferation arrest in cancer cells

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