Name: Glutaminyl Cyclase Inhibitor 3
Rating: 5 (10 reviews)

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HIT ID:HIT212671257
Cas No:2092921-50-9
常用名:Glutaminyl Cyclase Inhibitor 3
IUPAC:1-{4-[4-(2-aminopyridin-4-yl)butoxy]-3-methoxyphenyl}-3-[3-(5-methyl-1H-imidazol-1-yl)propyl]thiourea
IUPAC:1-{4-[4-(2-aminopyridin-4-yl)butoxy]-3-methoxyphenyl}-3-[3-(5-methyl-1H-imidazol-1-yl)propyl]thiourea
InChI key:MXAZSKBTKUGBLI-UHFFFAOYSA-N

分子式:C24H32N6O2S
分子量:468.62
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:3.1153364
SMILES:COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1
SMILES:COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1

Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.

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