Name: GSK2945 hydrochloride (1438071-12-5 free base)
Rating: 5 (10 reviews)

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HIT ID:HIT212671330
Cas No:2517771-89-8
常用名:GSK2945 hydrochloride (1438071-12-5 free base)
常用名:GSK2945 hydrochloride (1438071-12-5 free base)
别名:GSK2945 hydrochloride
IUPAC:[(4-chloro-2-methylphenyl)methyl][(4-chlorophenyl)methyl][(5-nitrothiophen-2-yl)methyl]amine hydrochloride
IUPAC:[(4-chloro-2-methylphenyl)methyl][(4-chlorophenyl)methyl][(5-nitrothiophen-2-yl)methyl]amine hydrochloride
InChI key:HRNMOPTYOFRUFF-UHFFFAOYSA-N

分子式:C20H19Cl3N2O2S
分子量:457.79
氢键供体数 (HBD):0
氢键受体数 (HBA):3
LogP:7.103961
SMILES:Cl.Cc1cc(Cl)ccc1CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1
SMILES:Cl.Cc1cc(Cl)ccc1CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1

GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.

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