Name: GSK3368715
Rating: 5 (10 reviews)

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HIT ID:HIT212671336
Cas No:1629013-22-4
常用名:GSK3368715
别名:EPZ019997
IUPAC:({3-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)(methyl)[2-(methylamino)ethyl]amine
IUPAC:({3-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)(methyl)[2-(methylamino)ethyl]amine
InChI key:SPEGERVLTUWZPA-UHFFFAOYSA-N

分子式:C20H38N4O2
分子量:366.55
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:2.1246884
SMILES:CCOCC1(COCC)CCC(CC1)c1n[nH]cc1CN(C)CCNC
SMILES:CCOCC1(COCC)CCC(CC1)c1n[nH]cc1CN(C)CCNC

GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). It has strong anti-cancer activity.

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