Name: GZD856
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212671366
Cas No:1257628-64-0
常用名:GZD856
IUPAC:4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{pyrazolo[1,5-a]pyrimidin-6-yl}ethynyl)benzamide
IUPAC:4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{pyrazolo[1,5-a]pyrimidin-6-yl}ethynyl)benzamide
InChI key:FSLXBWOKEGSUPS-UHFFFAOYSA-N

分子式:C29H27F3N6O
分子量:532.571
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:5.045713
SMILES:CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)cc2C(F)(F)F)CC1
SMILES:CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)cc2C(F)(F)F)CC1

GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.

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