Name: H4R antagonist 1
Rating: 5 (10 reviews)

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HIT ID:HIT212671376
Cas No:1429375-54-1
常用名:H4R antagonist 1
IUPAC:1-{12-bromo-2,3,4,5,8,10-hexaazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-yl}-N-methylazetidin-3-amine
IUPAC:1-{12-bromo-2,3,4,5,8,10-hexaazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-yl}-N-methylazetidin-3-amine
InChI key:ICGICUHMULRYIQ-UHFFFAOYSA-N

分子式:C11H11BrN8
分子量:335.169
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:1.0924132
SMILES:CNC1CN(C1)c1nc2ncc(Br)cc2n2nnnc12
SMILES:CNC1CN(C1)c1nc2ncc(Br)cc2n2nnnc12

H4R antagonist 1 is a highly selective histamine H4 receptor (H4R) antagonist (IC50: 27 nM). H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.

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