Name: HL271
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212671411
Cas No:1422365-52-3
常用名:HL271
IUPAC:N'-(pyrrolidine-1-carboximidoyl)-N-[4-(trifluoromethoxy)phenyl]guanidine hydrochloride
IUPAC:N'-(pyrrolidine-1-carboximidoyl)-N-[4-(trifluoromethoxy)phenyl]guanidine hydrochloride
InChI key:FSEAYPJRYNBFTN-UHFFFAOYSA-N

分子式:C13H17ClF3N5O
分子量:351.76
氢键供体数 (HBD):4
氢键受体数 (HBA):6
LogP:3.1025577
SMILES:Cl.FC(F)(F)Oc1ccc(NC(=N)NC(=N)N2CCCC2)cc1
SMILES:Cl.FC(F)(F)Oc1ccc(NC(=N)NC(=N)N2CCCC2)cc1

HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.

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