Name: UK-370106
Rating: 5 (10 reviews)

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HIT ID:HIT212671613
Cas No:230961-21-4
常用名:UK-370106
IUPAC:(3R)-3-{[(1S)-1-{[(1S)-2-methoxy-1-phenylethyl]carbamoyl}-2,2-dimethylpropyl]carbamoyl}-6-{2-methyl-[1,1'-biphenyl]-4-yl}hexanoic acid
IUPAC:(3R)-3-{[(1S)-1-{[(1S)-2-methoxy-1-phenylethyl]carbamoyl}-2,2-dimethylpropyl]carbamoyl}-6-{2-methyl-[1,1'-biphenyl]-4-yl}hexanoic acid
InChI key:NSMABJUGSNPHMN-BHYWQNONSA-N

分子式:C35H44N2O5
分子量:572.746
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:6.6556354
SMILES:COC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(c(C)c1)-c1ccccc1)CC(O)=O)C(C)(C)C)c1ccccc1
SMILES:COC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(c(C)c1)-c1ccccc1)CC(O)=O)C(C)(C)C)c1ccccc1

UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).

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