Name: VU6005806
Rating: 5 (10 reviews)

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HIT ID:HIT212671686
Cas No:2180914-37-6
常用名:VU6005806
别名:AZN-00016130
IUPAC:5-amino-3-methoxy-4-methyl-N-{1-[5-(trifluoromethyl)pyrimidin-2-yl]azetidin-3-yl}thieno[2,3-c]pyridazine-6-carboxamide
IUPAC:5-amino-3-methoxy-4-methyl-N-{1-[5-(trifluoromethyl)pyrimidin-2-yl]azetidin-3-yl}thieno[2,3-c]pyridazine-6-carboxamide
InChI key:VILQHBIGBISKQM-UHFFFAOYSA-N

分子式:C17H16F3N7O2S
分子量:439.42
氢键供体数 (HBD):2
氢键受体数 (HBA):8
LogP:2.4284587
SMILES:COc1nnc2sc(C(=O)NC3CN(C3)c3ncc(cn3)C(F)(F)F)c(N)c2c1C
SMILES:COc1nnc2sc(C(=O)NC3CN(C3)c3ncc(cn3)C(F)(F)F)c(N)c2c1C

VU6005806 is a potent positive allosteric modulator (PAM) of muscarinic acetylcholine receptor subtype 4 (M4) (EC50s: 94 nM, 28 nM, 87 nM, and 68 nM for human, rat, dog, and cyno M4, respectively), and used in the study of neuropsychiatric disorders.

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