Name: c-Fms-IN-6
Rating: 5 (10 reviews)

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HIT ID:HIT212671752
Cas No:1628574-81-1
常用名:c-Fms-IN-6
IUPAC:3-tert-butyl-1-(5-{[2-(1-ethyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}-6-methylpyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one
IUPAC:3-tert-butyl-1-(5-{[2-(1-ethyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}-6-methylpyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one
InChI key:NWTRDIYLEGZNSX-UHFFFAOYSA-N

分子式:C22H25N7O2
分子量:419.489
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:3.7298262
SMILES:CCn1cc(cn1)-c1cc(Oc2ccc(nc2C)-n2nc([nH]c2=O)C(C)(C)C)ccn1
SMILES:CCn1cc(cn1)-c1cc(Oc2ccc(nc2C)-n2nc([nH]c2=O)C(C)(C)C)ccn1

c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).

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