Name: JTK-853
Rating: 5 (10 reviews)

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HIT ID:HIT212671955
Cas No:954389-09-4
常用名:JTK-853
IUPAC:(2R)-4-{5-cyclopropyl-[1,3]thiazolo[4,5-d]pyrimidin-2-yl}-N-{[3-fluoro-4-(trifluoromethoxy)phenyl]methyl}-1-[4-(trifluoromethyl)benzenesulfonyl]piperazine-2-carboxamide
IUPAC:(2R)-4-{5-cyclopropyl-[1,3]thiazolo[4,5-d]pyrimidin-2-yl}-N-{[3-fluoro-4-(trifluoromethoxy)phenyl]methyl}-1-[4-(trifluoromethyl)benzenesulfonyl]piperazine-2-carboxamide
InChI key:JQLOVYLALGSISI-HXUWFJFHSA-N

分子式:C28H23F7N6O4S2
分子量:704.64
氢键供体数 (HBD):1
氢键受体数 (HBA):8
LogP:6.875409
SMILES:Fc1cc(CNC(=O)[C@H]2CN(CCN2S(=O)(=O)c2ccc(cc2)C(F)(F)F)c2nc3nc(ncc3s2)C2CC2)ccc1OC(F)(F)F
SMILES:Fc1cc(CNC(=O)[C@H]2CN(CCN2S(=O)(=O)c2ccc(cc2)C(F)(F)F)c2nc3nc(ncc3s2)C2CC2)ccc1OC(F)(F)F

JTK-853 is a novel, non-nucleoside inhibitor of Hepatitis C Virus (HCV) polymerase. It also displays effective antiviral activity in HCV replicon cells (EC50s: 0.38 and 0.035 μM in genotype 1a H77 and 1b Con1 strains, respectively).

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