Name: KZR-504
Rating: 5 (10 reviews)

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HIT ID:HIT212671994
Cas No:1629052-78-3
常用名:KZR-504
IUPAC:(2S)-3-hydroxy-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(6-oxo-1,6-dihydropyridin-2-yl)formamido]propanamide
IUPAC:(2S)-3-hydroxy-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(6-oxo-1,6-dihydropyridin-2-yl)formamido]propanamide
InChI key:QYDASSGXBXGRBS-CKJXQJPGSA-N

分子式:C21H23N3O6
分子量:413.43
氢键供体数 (HBD):4
氢键受体数 (HBA):6
LogP:-0.19043198
SMILES:C[C@@]1(CO1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)c1cccc(=O)[nH]1
SMILES:C[C@@]1(CO1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)c1cccc(=O)[nH]1

KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).

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