Name: Lidoflazine
Rating: 5 (10 reviews)

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HIT ID:HIT212672054
Cas No:3416-26-0
常用名:Lidoflazine
IUPAC:2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-N-(2,6-dimethylphenyl)acetamide
IUPAC:2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-N-(2,6-dimethylphenyl)acetamide
InChI key:ZBIAKUMOEKILTF-UHFFFAOYSA-N

分子式:C30H35F2N3O
分子量:491.627
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:6.5849156
SMILES:Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
SMILES:Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1

Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia.

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