Name: CMLD012072
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT212672059
Cas No:2368900-33-6
常用名:CMLD012072
IUPAC:methyl (1R,9R,10S,11R,12R)-14-cyclopropyl-12-hydroxy-3,5-dimethoxy-9-(4-methoxyphenyl)-10-phenyl-8-oxa-13,15-diazatetracyclo[7.6.0.0^{1,12}.0^{2,7}]pentadeca-2(7),3,5,13-tetraene-11-carboxylate
IUPAC:methyl (1R,9R,10S,11R,12R)-14-cyclopropyl-12-hydroxy-3,5-dimethoxy-9-(4-methoxyphenyl)-10-phenyl-8-oxa-13,15-diazatetracyclo[7.6.0.0^{1,12}.0^{2,7}]pentadeca-2(7),3,5,13-tetraene-11-carboxylate
InChI key:KAEUWSZLWVZGMK-GAFFYMCOSA-N

分子式:C32H32N2O7
分子量:556.615
氢键供体数 (HBD):2
氢键受体数 (HBA):8
LogP:4.0621076
SMILES:COC(=O)[C@@H]1[C@@H](c2ccccc2)[C@@]2(Oc3cc(OC)cc(OC)c3[C@@]22NC(=N[C@@]12O)C1CC1)c1ccc(OC)cc1 |c:29|
SMILES:COC(=O)[C@@H]1[C@@H](c2ccccc2)[C@@]2(Oc3cc(OC)cc(OC)c3[C@@]22NC(=N[C@@]12O)C1CC1)c1ccc(OC)cc1 |c:29|

CMLD012072 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor with potent anti-neoplastic activity. It can induce RNA clamping of eIF4A1 and eIF4A2.

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