Name: CP-10
Rating: 5 (10 reviews)

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HIT ID:HIT212672086
Cas No:2366268-80-4
常用名:CP-10
IUPAC:4-[(2-{2-[4-({4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC:4-[(2-{2-[4-({4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
InChI key:PACRWHUPEPCFHX-UHFFFAOYSA-N

分子式:C44H49N13O7
分子量:871.96
氢键供体数 (HBD):3
氢键受体数 (HBA):16
LogP:2.619
SMILES:CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(Cc4cn(CCOCCNc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)CC3)nc2n(C2CCCC2)c1=O
SMILES:CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(Cc4cn(CCOCCNc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)CC3)nc2n(C2CCCC2)c1=O

CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.

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