Name: (1S,3R,5R)-PIM447 dihydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212672274
Cas No:2096989-57-8
常用名:(1S,3R,5R)-PIM447 dihydrochloride
常用名:(1S,3R,5R)-PIM447 dihydrochloride
别名:(1S,3R,5R)-LGH447 dihydrochloride
IUPAC:N-{4-[(1S,3R,5R)-3-amino-5-methylcyclohexyl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide dihydrochloride
IUPAC:N-{4-[(1S,3R,5R)-3-amino-5-methylcyclohexyl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide dihydrochloride
InChI key:BVRSHQQSBGCMJE-ISUJJMBGSA-N

分子式:C24H25Cl2F3N4O
分子量:513.39
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:4.182393
SMILES:Cl.Cl.C[C@H]1C[C@@H](N)C[C@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
SMILES:Cl.Cl.C[C@H]1C[C@@H](N)C[C@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F

(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).

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