Name: J-2156
Rating: 5 (10 reviews)

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HIT ID:HIT212672389
Cas No:848647-56-3
常用名:J-2156
IUPAC:(2S)-4-amino-N-[(1S)-1-carbamoyl-2-phenylethyl]-2-(4-methylnaphthalene-1-sulfonamido)butanamide
IUPAC:(2S)-4-amino-N-[(1S)-1-carbamoyl-2-phenylethyl]-2-(4-methylnaphthalene-1-sulfonamido)butanamide
InChI key:VTNCZBXJSGKDLS-SFTDATJTSA-N

分子式:C24H28N4O4S
分子量:468.57
氢键供体数 (HBD):4
氢键受体数 (HBA):5
LogP:1.2425042
SMILES:Cc1ccc(c2ccccc12)S(=O)(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
SMILES:Cc1ccc(c2ccccc12)S(=O)(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively. J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively.

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