Name: J22352
Rating: 5 (10 reviews)

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HIT ID:HIT212672390
Cas No:2252395-44-9
常用名:J22352
IUPAC:4-{[2,4-dioxo-3-(2-phenylethyl)-1,2,3,4-tetrahydroquinazolin-1-yl]methyl}-N-hydroxybenzamide
IUPAC:4-{[2,4-dioxo-3-(2-phenylethyl)-1,2,3,4-tetrahydroquinazolin-1-yl]methyl}-N-hydroxybenzamide
InChI key:JBJIKUXUKSADFV-UHFFFAOYSA-N

分子式:C24H21N3O4
分子量:415.449
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:3.4197557
SMILES:ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccccc3)c2=O)cc1
SMILES:ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccccc3)c2=O)cc1

J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.

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