Name: JAK2-IN-4
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT212672396
Cas No:1438284-00-4
常用名:JAK2-IN-4
IUPAC:4-{5-methanesulfonyl-4H,5H,6H,7H-furo[3,2-c]pyridin-2-yl}-5-methyl-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine
IUPAC:4-{5-methanesulfonyl-4H,5H,6H,7H-furo[3,2-c]pyridin-2-yl}-5-methyl-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine
InChI key:YDZHOVOPBMIATL-UHFFFAOYSA-N

分子式:C23H27N5O4S
分子量:469.56
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:2.0592525
SMILES:Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1cc2CN(CCc2o1)S(C)(=O)=O
SMILES:Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1cc2CN(CCc2o1)S(C)(=O)=O

JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.

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