Name: JTE-952
Rating: 5 (10 reviews)

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HIT ID:HIT212672417
Cas No:1255303-54-8
常用名:JTE-952
IUPAC:(2S)-3-{[2-(3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidine-1-carbonyl)pyridin-4-yl]methoxy}propane-1,2-diol
IUPAC:(2S)-3-{[2-(3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidine-1-carbonyl)pyridin-4-yl]methoxy}propane-1,2-diol
InChI key:LTTJGQBDGMNWHJ-SANMLTNESA-N

分子式:C30H34N2O6
分子量:518.61
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:2.686732
SMILES:COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1
SMILES:COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1

JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

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