Name: KDOAM-25
Rating: 5 (10 reviews)

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HIT ID:HIT212672439
Cas No:2230731-99-2
常用名:KDOAM-25
IUPAC:2-{[({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridine-4-carboxamide
IUPAC:2-{[({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridine-4-carboxamide
InChI key:PNFMVADNCOGWME-UHFFFAOYSA-N

分子式:C15H25N5O2
分子量:307.398
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:-1.2601203
SMILES:CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(N)=O
SMILES:CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(N)=O

KDOAM-25, a potent and highly selective inhibitor of histone lysine demethylases 5 (KDM5) with IC50 values of 71 nM for KDM5A, 19 nM for KDM5B, 69 nM for KDM5C, and 69 nM for KDM5D, enhances global H3K4 methylation at transcriptional start sites and reduces proliferation in multiple myeloma MM1S cells.

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