Name: LX2761
Rating: 5 (10 reviews)

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HIT ID:HIT212672476
Cas No:1610954-97-6
常用名:LX2761
IUPAC:N-(1-{[2-(dimethylamino)ethyl]carbamoyl}-1-methylethyl)-4-[4-({2-methyl-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]phenyl}methyl)phenyl]butanamide
IUPAC:N-(1-{[2-(dimethylamino)ethyl]carbamoyl}-1-methylethyl)-4-[4-({2-methyl-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]phenyl}methyl)phenyl]butanamide
InChI key:BNPZTRDIESRGTC-IXYVTWBDSA-N

分子式:C32H47N3O6S
分子量:601.8
氢键供体数 (HBD):5
氢键受体数 (HBA):7
LogP:3.2998796
SMILES:CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)NCCN(C)C)cc2)c1
SMILES:CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)NCCN(C)C)cc2)c1

LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the gastrointestinal (GI) tract.

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