Name: LY309887
Rating: 5 (10 reviews)

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HIT ID:HIT212672490
Cas No:127228-54-0
常用名:LY309887
IUPAC:(2S)-2-[(5-{2-[(6R)-2-amino-4-oxo-3H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}thiophen-2-yl)formamido]pentanedioic acid
IUPAC:(2S)-2-[(5-{2-[(6R)-2-amino-4-oxo-3H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}thiophen-2-yl)formamido]pentanedioic acid
InChI key:GQCXGHHHNACOGE-SKDRFNHKSA-N

分子式:C19H23N5O6S
分子量:449.48
氢键供体数 (HBD):6
氢键受体数 (HBA):9
LogP:-0.78344935
SMILES:Nc1nc2NC[C@H](CCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
SMILES:Nc1nc2NC[C@H](CCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.

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