Name: LY367385
Rating: 5 (10 reviews)

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HIT ID:HIT212672495
Cas No:198419-91-9
常用名:LY367385
IUPAC:4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid
IUPAC:4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid
InChI key:SGIKDIUCJAUSRD-QMMMGPOBSA-N

分子式:C10H11NO4
分子量:209.201
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:-1.3640523
SMILES:Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O
SMILES:Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O

LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM for mGlu5a, LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis.

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