Name: L-873724
Rating: 5 (10 reviews)

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HIT ID:HIT212672556
Cas No:603139-12-4
常用名:L-873724
IUPAC:(2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-{4'-methanesulfonyl-[1,1'-biphenyl]-4-yl}ethyl]amino}pentanamide
IUPAC:(2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-{4'-methanesulfonyl-[1,1'-biphenyl]-4-yl}ethyl]amino}pentanamide
InChI key:VYFDSJLOCIGIKP-SFTDATJTSA-N

分子式:C23H26F3N3O3S
分子量:481.53
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:3.2875152
SMILES:CC(C)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NCC#N
SMILES:CC(C)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NCC#N

L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of 0.5 nM for rabbit cathepsin K.

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