Name: MK-8318
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212672561
Cas No:1416581-40-2
常用名:MK-8318
IUPAC:3-{[(3aS,9R,9aR)-7-fluoro-4-[4-(trifluoromethoxy)benzoyl]-1H,2H,3H,3aH,4H,9H,9aH-cyclopenta[b]quinolin-9-yl](cyclopropyl)carbamoyl}propanoic acid
IUPAC:3-{[(3aS,9R,9aR)-7-fluoro-4-[4-(trifluoromethoxy)benzoyl]-1H,2H,3H,3aH,4H,9H,9aH-cyclopenta[b]quinolin-9-yl](cyclopropyl)carbamoyl}propanoic acid
InChI key:BNMORDXQPYWZBW-FZOAFFARSA-N

分子式:C27H26F4N2O5
分子量:534.508
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:4.8646255
SMILES:OC(=O)CCC(=O)N(C1CC1)[C@@H]1[C@@H]2CCC[C@@H]2N(C(=O)c2ccc(OC(F)(F)F)cc2)c2ccc(F)cc12
SMILES:OC(=O)CCC(=O)N(C1CC1)[C@@H]1[C@@H]2CCC[C@@H]2N(C(=O)c2ccc(OC(F)(F)F)cc2)c2ccc(F)cc12

MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).

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