Name: MRT00033659
Rating: 5 (10 reviews)

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HIT ID:HIT212672591
Cas No:1401731-54-1
常用名:MRT00033659
IUPAC:N-(3-{3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)acetamide
IUPAC:N-(3-{3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)acetamide
InChI key:YFBPGSDPFRCNOY-UHFFFAOYSA-N

分子式:C15H14N4O
分子量:266.304
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:1.4624032
SMILES:CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
SMILES:CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1

MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.

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