MRT199665 | CAS 1456858-57-3 | AnyMole

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HIT212672592

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HIT212672592

HIT ID:HIT212672592
Cas No:1456858-57-3
常用名:MRT199665
IUPAC:7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
IUPAC:7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
InChI key:OFIFLUFVENTCNZ-QHCPKHFHSA-N

分子式:C28H31N5O2
分子量:469.589
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:4.552842
SMILES:CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3cccc(CN4CCCC4)c3)ncc12
SMILES:CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3cccc(CN4CCCC4)c3)ncc12

MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively). MRT199665 suppresses the phosphorylation of SIK substrate CRTC3 at S370. MRT199665 induces apoptosis in MEF2C-activated human acute myeloid leukemia (AML) cells.

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TargetMolSC
规格
货期
8-10周
纯度
-
待询
1

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