Name: PF-4693627
Rating: 5 (10 reviews)

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HIT ID:HIT212672838
Cas No:1312815-93-2
常用名:PF-4693627
IUPAC:1-[5-chloro-6-(4-chlorophenyl)-1,3-benzoxazol-2-yl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamide
IUPAC:1-[5-chloro-6-(4-chlorophenyl)-1,3-benzoxazol-2-yl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamide
InChI key:CPDNPVKDQXLYHO-JXFKEZNVSA-N

分子式:C26H29Cl2N3O3
分子量:502.44
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:5.1848826
SMILES:OC[C@H]1CCC[C@@H](C1)NC(=O)C1CCN(CC1)c1nc2cc(Cl)c(cc2o1)-c1ccc(Cl)cc1
SMILES:OC[C@H]1CCC[C@@H](C1)NC(=O)C1CCN(CC1)c1nc2cc(Cl)c(cc2o1)-c1ccc(Cl)cc1

PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).

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