Name: PR-924
Rating: 5 (10 reviews)

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HIT ID:HIT212672888
Cas No:1416709-79-9
常用名:PR-924
IUPAC:(2S)-3-(1H-indol-3-yl)-2-[(2R)-2-[(3-methyl-1H-inden-2-yl)formamido]propanamido]-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]propanamide
IUPAC:(2S)-3-(1H-indol-3-yl)-2-[(2R)-2-[(3-methyl-1H-inden-2-yl)formamido]propanamido]-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]propanamide
InChI key:ADBUEVSHEJICCM-LZNHGOJSSA-N

分子式:C37H38N4O5
分子量:618.734
氢键供体数 (HBD):4
氢键受体数 (HBA):5
LogP:4.8667173
SMILES:C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |c:5|
SMILES:C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |c:5|

PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N-terminal threonine active sites.

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