Name: Eltanexor Z-isomer
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT212672937
Cas No:1642300-78-4
常用名:Eltanexor Z-isomer
别名:KPT-8602 (Z-isomer)
IUPAC:(2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)prop-2-enamide
IUPAC:(2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)prop-2-enamide
InChI key:JFBAVWVBLRIWHM-MLPAPPSSSA-N

分子式:C17H10F6N6O
分子量:428.298
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:2.6789536
SMILES:NC(=O)C(=C/n1cnc(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)\c1cncnc1
SMILES:NC(=O)C(=C/n1cnc(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)\c1cncnc1

Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.

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