Name: Lanraplenib monosuccinate
Rating: 5 (10 reviews)

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HIT ID:HIT212673000
Cas No:1800046-97-2
常用名:Lanraplenib monosuccinate
别名:GS-9876 monosuccinate
IUPAC:6-[8-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]pyrazin-2-amine; butanedioic acid
IUPAC:6-[8-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]pyrazin-2-amine; butanedioic acid
InChI key:DVFRSTNNWJHWGW-UHFFFAOYSA-N

分子式:C27H31N9O5
分子量:561.603
氢键供体数 (HBD):2
氢键受体数 (HBA):9
LogP:1.121803
SMILES:OC(=O)CCC(O)=O.Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
SMILES:OC(=O)CCC(O)=O.Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1

Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib monosuccinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.

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