Name: Leelamine hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212673014
Cas No:16496-99-4
常用名:Leelamine hydrochloride
别名:脱氢松香胺盐酸盐
IUPAC:1-[(1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methanamine hydrochloride
IUPAC:1-[(1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methanamine hydrochloride
InChI key:CVPQLGCAWUAYPF-WFBUOHSLSA-N

分子式:C20H32ClN
分子量:321.93
氢键供体数 (HBD):1
氢键受体数 (HBA):1
LogP:5.1694193
SMILES:Cl.[H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(C)CN)C(C)C
SMILES:Cl.[H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(C)CN)C(C)C

Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.

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