Name: Rhosin
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT212673037
Cas No:1173671-63-0
常用名:Rhosin
IUPAC:(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(quinoxalin-6-yl)methylidene]propanehydrazide
IUPAC:(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(quinoxalin-6-yl)methylidene]propanehydrazide
InChI key:FGYHLIHEFHCMPP-FVWOBLMASA-N

分子式:C20H18N6O
分子量:358.405
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:1.8345156
SMILES:N[C@H](Cc1c[nH]c2ccccc12)C(=O)N\N=C\c1ccc2nccnc2c1
SMILES:N[C@H](Cc1c[nH]c2ccccc12)C(=O)N\N=C\c1ccc2nccnc2c1

Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin causes cell apoptosis.

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