Name: LY3020371 hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212673172
Cas No:1377615-44-5
常用名:LY3020371 hydrochloride
IUPAC:(1S,2R,3S,4S,5R,6R)-2-amino-3-{[(3,4-difluorophenyl)sulfanyl]methyl}-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride
IUPAC:(1S,2R,3S,4S,5R,6R)-2-amino-3-{[(3,4-difluorophenyl)sulfanyl]methyl}-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride
InChI key:XETSGLSGWGGOTN-JPWNOPPSSA-N

分子式:C15H16ClF2NO5S
分子量:395.8
氢键供体数 (HBD):4
氢键受体数 (HBA):6
LogP:-1.7381586
SMILES:Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(F)c1)[C@H]2O)C(O)=O
SMILES:Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(F)c1)[C@H]2O)C(O)=O

LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.

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