Name: SPL-707
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212673333
Cas No:2195361-33-0
常用名:SPL-707
IUPAC:(2S)-2-cyclopropyl-N-[(9'S)-2',8'-dioxo-3',7'-diazaspiro[cyclopropane-1,5'-tricyclo[8.4.0.0^{3,7}]tetradecane]-1'(10'),11',13'-trien-9'-yl]-N'-(5-fluoro-2-methylpyridin-3-yl)butanediamide
IUPAC:(2S)-2-cyclopropyl-N-[(9'S)-2',8'-dioxo-3',7'-diazaspiro[cyclopropane-1,5'-tricyclo[8.4.0.0^{3,7}]tetradecane]-1'(10'),11',13'-trien-9'-yl]-N'-(5-fluoro-2-methylpyridin-3-yl)butanediamide
InChI key:WLQXBRYTQYYCMW-REWPJTCUSA-N

分子式:C27H28FN5O4
分子量:505.55
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:1.0624857
SMILES:Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O
SMILES:Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O

SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).

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