Name: Streptolydigin
Rating: 5 (10 reviews)

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HIT ID:HIT212673348
Cas No:7229-50-7
常用名:Streptolydigin
别名:Portamycin
IUPAC:(2S)-2-[(2S,4E)-4-[(2E,4E,6R)-6-[(1R,2R,5R,6S,7S)-1,6-dimethyl-8,9-dioxaspiro[bicyclo[3.3.1]nonane-2,2'-oxiran]-3-en-7-yl]-1-hydroxy-4-methylhepta-2,4-dien-1-ylidene]-1-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]-3,5-dioxopyrrolidin-2-yl]-N-methylpropanamide
IUPAC:(2S)-2-[(2S,4E)-4-[(2E,4E,6R)-6-[(1R,2R,5R,6S,7S)-1,6-dimethyl-8,9-dioxaspiro[bicyclo[3.3.1]nonane-2,2'-oxiran]-3-en-7-yl]-1-hydroxy-4-methylhepta-2,4-dien-1-ylidene]-1-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]-3,5-dioxopyrrolidin-2-yl]-N-methylpropanamide
InChI key:KVTPRMVXYZKLIG-NCAOFHFGSA-N

分子式:C32H44N2O9
分子量:600.709
氢键供体数 (HBD):3
氢键受体数 (HBA):9
LogP:2.085019
SMILES:[H][C@@]1([C@H](C)C(=O)NC)N(C(=O)\C(=C(\O)/C=C/C(/C)=C/[C@@H](C)[C@@]2([H])O[C@@]3(C)O[C@H](C=C[C@@]33CO3)[C@@H]2C)C1=O)[C@]1([H])CC[C@H](O)[C@H](C)O1 |c:28|
SMILES:[H][C@@]1([C@H](C)C(=O)NC)N(C(=O)\C(=C(\O)/C=C/C(/C)=C/[C@@H](C)[C@@]2([H])O[C@@]3(C)O[C@H](C=C[C@@]33CO3)[C@@H]2C)C1=O)[C@]1([H])CC[C@H](O)[C@H](C)O1 |c:28|

Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM).

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