Name: TAK-915
Rating: 5 (10 reviews)

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HIT ID:HIT212673363
Cas No:1476727-50-0
常用名:TAK-915
IUPAC:N-[(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-4-carboxamide
IUPAC:N-[(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-4-carboxamide
InChI key:AWJSRXUQLSPAOI-CQSZACIVSA-N

分子式:C19H18F4N4O5
分子量:458.37
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:2.434384
SMILES:COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc12)c1ccc(OC(F)(F)F)c(F)c1
SMILES:COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc12)c1ccc(OC(F)(F)F)c(F)c1

TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM) with >4100-fold selectivity for PDE2A over PDE1A.

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