TAS05567 | CAS 1429038-15-2 | AnyMole

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HIT212673380

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HIT212673380

HIT ID:HIT212673380
Cas No:1429038-15-2
常用名:TAS05567
IUPAC:3-{[(3R,4R)-3-aminooxan-4-yl]amino}-5-[(2-tert-butyl-7-methyl-2H-indazol-5-yl)amino]-1,2,4-triazine-6-carboxamide
IUPAC:3-{[(3R,4R)-3-aminooxan-4-yl]amino}-5-[(2-tert-butyl-7-methyl-2H-indazol-5-yl)amino]-1,2,4-triazine-6-carboxamide
InChI key:ATERGQQFFHVNOJ-LSDHHAIUSA-N

分子式:C21H29N9O2
分子量:439.524
氢键供体数 (HBD):4
氢键受体数 (HBA):9
LogP:2.3269813
SMILES:Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(nc12)C(C)(C)C
SMILES:Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(nc12)C(C)(C)C

TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR, and RET with IC50s of 10 nM, 4.8 nM, 600 nM, and 29 nM, respectively) in a panel of 192 kinases.

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TargetMolSC
规格
货期
8-10周
纯度
-
¥ 13,800.00
1

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