Name: PF-06737007
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212673455
Cas No:1863905-38-7
常用名:PF-06737007
IUPAC:2-{[(3R,4S)-3-fluoro-1-{2-[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide
IUPAC:2-{[(3R,4S)-3-fluoro-1-{2-[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide
InChI key:AUTGNDRENPBZKA-UXHICEINSA-N

分子式:C25H28F4N2O6
分子量:528.501
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:3.2355423
SMILES:CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1
SMILES:CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1

PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).

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