Name: Auglurant
Rating: 5 (10 reviews)

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HIT ID:HIT212673506
Cas No:1396337-04-4
常用名:Auglurant
别名:VU0424238
IUPAC:N-(5-fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)pyridine-2-carboxamide
IUPAC:N-(5-fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)pyridine-2-carboxamide
InChI key:RBAHIIPVJVMACF-UHFFFAOYSA-N

分子式:C16H12FN5O2
分子量:325.303
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:1.4609425
SMILES:Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(F)cn1
SMILES:Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(F)cn1

Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration.

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