Name: VU0467485
Rating: 5 (10 reviews)

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HIT ID:HIT212673509
Cas No:1451994-10-7
常用名:VU0467485
别名:AZ13713945
IUPAC:5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
IUPAC:5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
InChI key:VFNHDIWHQGVWLL-UHFFFAOYSA-N

分子式:C17H17FN4O2S
分子量:360.41
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:2.4014153
SMILES:COc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1F
SMILES:COc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1F

VU0467485 is a potent and selective muscarinic acetylcholine receptor 4 positive allosteric modulator. VU0467485 potentiates the activity of ACh at M4 (EC50s: 26.6 nM and 78.8 nM at the rat and human M4 receptors, respectively). VU0467485 displays selectivity for M4 over human and rat M1/2/3/5.

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